Trade Name: Arimidex
Routes Of Administration: By mouth (tablets)
Protein binding: 40%
Metabolism: Liver (85%)
Biological Half-Life: 46.8 h
CAS Number: 120511-73-1
Molar Mass: 293.366 g/mol
Transport Package: Foil Bag
Use: Treat Breast Cancer After Surgery
Appearance: White crystalline powder.
Arimidex Origin: China
Anastrozole, sold under the trade name Arimidex among others, is a medication used in addition to other treatments for breast cancer. Is is also called Arimidex. It is a type of hormone therapy called an aromatase inhibitor. Anastrozole treats advanced breast cancer in women who have had their menopause Specifically it is used for hormone receptor-positive breast cancer. It has also been used to prevent breast cancer in those at high risk. It is taken by mouth.Anastrozole was patented in 1987 and approved for medical use in 1995.It is on the World Health Organization’s List of Essential Medicines, the most effective and safe medicines needed in a health system. Anastrozole is available as a generic medication.
Anastrozole Medical Uses
The ATAC trial was of localized breast cancer and women received either anastrozole, tamoxifen, or both for five years, followed by five years of follow-up. After more than 5 years the group that received anastrozole had better results than the tamoxifen group. The trial suggested that anastrozole is the preferred medical therapy for postmenopausal women with localized breast cancer, which is estrogen receptor (ER) positive. Another study found that the risk of recurrence was reduced by 40%, but was associated with an increased risk of bone fractures. The study concluded that ER positive patients benefited from switching from tamoxifen to anastrozole in patients who have completed 2 years’ adjuvant tamoxifen. A more recent trial found that anastrozole significantly reduced the incidence of breast cancer in postmenopausal women relative to placebo, and while there were side effects related to estrogen deprivation observed, the researchers concluded that this was probably not related to the treatment. Lead author Jack Cuzick was quoted by the BBC as saying, “This class of drugs is more effective than previous drugs such as tamoxifen and crucially, it has fewer side effects,” adding that he thought there was now enough evidence to support offering the drug.
Anastrozole Usage In Men
Anastrozole has been tested for reducing estrogens, including estradiol, in men. Excess estradiol in men can cause benign prostatic hyperplasia, gynecomastia, and symptoms of hypogonadism. It can also contribute to increased risk of stroke, heart attack, chronic inflammation, prostate enlargement and prostate cancer. Some athletes and body builders use anastrozole as part of their steroid cycle to reduce and prevent symptoms of excess estrogen–gynecomastia, emotional lability and water retention. Study data suggest dosages of 0.5 mg to 1 mg a day reduce serum estradiol by approximately 50% in men, which differs in postmenopausal women.
Usage in children
Anastrozole may be used off-label in children with precocious puberty, or children with pubertal gynecomastia. Following the onset of puberty, the epiphyseal plate begins to close due to an increased amount of estrogen production escaping local metabolism and spreading to the circulatory system. It is shown to help slow this process, and increase adult height prediction in adolescent males treated with protein-based peptide hormones for the treatment of growth hormone deficiency.